Research Scientist CAR T cells

Poseida Therapeutics, Inc. is seeking an outstanding candidate to join our immuno-oncology team at La Jolla, San Diego, CA. Prior hands-on experience developing, testing, and/or utilizing CARs is required. The Scientist will design and perform experiments for the development of chimeric antigen receptor (CAR)-T cell therapies against cancer. Investigation will focus on in vitro human cell based immunoassays and the coordination of in vivo rodent models of malignancy. The position will play a critical role in the evaluation and identification of lead CAR technologies for clinical evaluation. The successful candidate will demonstrate excellent oral and written communication skills, work well independently and as part of a team, and be able to work on multiple projects simultaneously. Broad expertise in cellular immunology, tumor immunology, molecular biology, and flow cytometry is required for this role. The position is a hands-on, laboratory-based role with the possibility of direct reports.

Poseida Therapeutics is translating best-in-class gene engineering technologies into lifesaving cell therapies. The company is developing CAR T-cell immunotherapies for multiple myeloma, prostate and other cancer types, as well as gene therapies for orphan diseases. P-BCMA-101 is Poseida’s lead CAR-T therapy currently in Phase 1 clinical development for the treatment of multiple myeloma. Poseida has assembled a suite of industry-leading gene engineering technologies, including the piggyBac™ DNA Modification System, TAL-CLOVER™ and Cas-CLOVER™ site-specific nucleases, and Footprint-Free™ Gene Editing (FFGE). For more information, visit www.poseida.com.

Qualifications
Required Experience and Skills:

  • PhD or equivalent in immunology, molecular biology, or related field and ≥ 2 years of experience in the field
  • Hands-on experience developing, testing, and/or utilizing CARs
  • Expertise in the characterization, culture, expansion, and manipulation of T cells
  • A detailed knowledge of cellular and/or tumor immunology principles, technologies, and experimental techniques (cell culture, in vitro cellular assays, flow cytometry, etc…)
  • Multi-parameter flow cytometry and proficiency in FACS data analysis programs
  • Functional assays measuring cellular activation, cytokine release, proliferation, and killing
  • Molecular biology, Cloning and PCR technologies, genetic manipulation
  • Electroporation techniques and technologies (Plasmid DNA, IVT RNA)
  • Cell separation technologies (e.g., Miltenyi AutoMACS) and FACS sorting
  • Demonstrated track record in successfully developing and employing in vitro/in vivo models
  • Ability to organize, communicate, and present complex data sets to key stakeholders from diverse backgrounds
  • Excellent oral and communication skills

Preferred Experience and Skills:

    • Genetic manipulation using CRISPRs, TALENs, or ZFNs
    • Strong understanding of transplantation biology and the role of histocompatibility antigens
    • Murine tumor models (genetically engineered or syngeneic)
    • Work with external academic, biotechnology, and contract research organizations
    • Mentor and guide other scientists in the group as needed
    • Previous supervisory skills