Description

Poseida Therapeutics, Inc. is seeking a talented, innovative, and self-motivated research scientist to join our Research and Development team at La Jolla, San Diego, CA. This position offers an excellent opportunity for a highly motivated individual to develop new gene editing and gene therapy products in an exciting and dynamic environment focused on cutting-edge gene editing technology. The Research Scientist will have a PhD or equivalent in molecular biology, biochemistry, cell biology, or related field, ideally with 2+ years of industry experience. Primarily, the role will:

  • Further develop our gene editing and gene therapy platform technologies, including XTNTM and RTNTM TALEN, NextGENTM CRISPR, piggyBacTM and Footprint-FreeTM Gene Editing
  • Develop assays, plan and perform experiments related to platform technology development
  • Analyze data and report to multidisciplinary groups
  • Assist the Gene Editing, Gene Therapy,  and Immuno-Oncology groups with product development
  • Attend scientific meetings, present results and evaluate and report on research
  • Keep current on trends, new products and technologies in the gene therapy and gene editing fields
  • Manage 1-2 Research Technicians or Research Associates
  • Report to the Associate Director of R&D

Poseida is a spinout of Transposagen Biopharmaceuticals, Inc., a leader in gene editing technologies. Poseida is currently developing CAR-T and gene therapy products for cancer and orphan liver diseases.  Poseida is also partnered with J&J’s Janssen to develop allogeneic CAR-T therapies against cancer.  Poseida has best-in-class genome engineering for stable transgene integration or targeted gene editing.  Proprietary platform technologies include piggyBac™ DNA Modification System (capable of delivering 300kb+ of cargo for stable integration and long-term expression), Footprint-Free™ Gene Editing System, NextGEN™ CRISPR, and XTN™ TALEN site-specific nucleases. Poseida aims to advance the first CAR-T product against multiple myeloma and gene therapy product against Progressive Familial Intraheptic Cholestasis 3.  Please visit www.poseida.com for more information.

Qualifications

Required Experience and Skills:

  • PhD or equivalent in molecular biology, biochemistry, cell biology, or related field and 2+ years of experience in the field, ideally in industry
  • Expertise with a range of molecular biology and cell biology techniques, such as PCR, qPCR and molecular cloning, protein expression and purification, mammalian cell culture and transfection, stable cell line generation, fluorescence imaging, protein expression and purification
  • Experience with Next Generation sequencing and library preparation
  • Experience with flow cytometry and immune-staining (IHC/IFC)
  • Demonstrated expertise in gene editing and genome engineering
  • Experience with gene delivery techniques such as transposon, AAV and retroviral vectors preferred
  • Broad knowledge of DNA repair pathways is a plus
  • Proven track record in creative thinking and assay development
  • Demonstrated ability to be independent, self-motivated, as well as work in a highly collaborative setting
  • Ability to work in a fast-paced environment and on multiple projects
  • Excellent oral and written communication skills, and documentation skills
  • Excellent critical thinking, analytic skills and great trouble-shooting ability are required
  • Must be passionate about performing research that may lead to the treatment or cure of human disease