Description

Poseida Therapeutics, Inc. is seeking a talented and self-motivated scientist to join our Gene Therapy team at our San Diego, CA, location. This position offers an excellent opportunity for a highly motivated individual to develop new gene editing and gene therapy products in an exciting and dynamic environment focused on cutting-edge gene editing technology. The Research Scientist will have a PhD or equivalent in molecular biology, cell biology, virology or related field, ideally with 2+ years of industry experience in gene delivery to hematopoietic stem cells (HSCs). Primarily, the role will:

  • – Process, isolate and characterize human hematopoietic cells from bone marrow and mobilized peripheral blood
  • – Oversee primary cell culture for hematopoietic progenitor and stem cell function and flow cytometric analysis
  • – Explore different culture methods for expanding and evaluating HSCs ex vivo
  • – Use our proprietary gene therapy platform technologies, including XTNTM and RTNTM TALEN, NextGENTM CRISPR, piggyBacTM and Footprint-FreeTM Gene Editing to create new human therapeutic candidates
  • – Application of gene delivery platforms including electroporation, nanoparticles, and viral transduction
  • – Evaluate diverse approaches to optimize gene editing and gene transfer into primary cells, including in vitro experiments and preclinical in vivo studies
  • – Implement and coordinate novel strategies utilizing gene modified cells for correcting genetic diseases
  • – Analyze data and report to multidisciplinary groups
  • – Attend scientific meetings, present results and evaluate and report on research
  • – Keep current on trends, new products and technologies in the gene therapy and gene editing fields
  • – Manage 1-2 Research Technicians or Research Associates
  • – Report to the Senior Director of Gene Therapy

Poseida Therapeutics is translating best-in-class gene editing technologies into lifesaving treatments. The company is developing CAR T-cell immunotherapies for multiple myeloma and other cancer types, as well as gene therapies for orphan diseases. Poseida has assembled a suite of industry-leading gene editing technologies, including the piggyBac™ DNA Modification System, XTN™ TALEN and NextGEN™ CRISPR site-specific nucleases, and Footprint-Free™ Gene Editing (FFGE).  For more information, visit poseida.com.

Qualifications

Required Experience and Skills:

PhD or equivalent in molecular biology, cell biology, virology or other relevant field and, ideally, 2+ years of industry experience in HSC biology and vector development.  However, candidates with comparable experience in academic environment are also encouraged to apply.

  • Established publication record and deep understanding of HSC biology and its potential application in gene therapy in vivo models and expression optimization in target cells.
  • Experience with lentivirus, retrovirus, adenovirus and AAV vectors is highly desirable
  • Experience with flow cytometry and immune-staining (IHC/IFC)
  • Basic knowledge in gene editing, genome engineering, and of gene delivery techniques using transposon is highly desirable
  • Demonstrated ability to be independent, self-motivated, as well as work in a highly collaborative setting
  • Ability to work on multiple projects at once
  • Excellent oral and written communication skills
  • Excellent documentation skills
  • Excellent critical thinking and analytic skills and great trouble-shooting ability are required
  • Must be passionate about performing research that may lead to the treatment or cure of human disease