Description

Poseida Therapeutics, Inc. is seeking a talented and self-motivated research associate to join our Gene Therapy team at our San Diego, CA, location. This position offers an excellent opportunity for a highly motivated individual to develop new gene editing and gene therapy products in an exciting and dynamic environment focused on cutting-edge gene editing technology. The Research Associate will have a MS or equivalent in molecular biology, cell biology, hematology, virology or related field, ideally with 2+ years of industry experience. Primarily, the role will:

  • Use our proprietary gene editing and gene therapy platform technologies, including XTNTM and RTNTM TALEN, NextGENTM CRISPR, piggyBacTM and Footprint-FreeTM Gene Editing, to create new human therapeutic candidates
  • Develop and perform research involving various cell biology techniques including transfection, transduction and culture of hematopoietic cells
  • Analyze data from cell-based assays and report to multidisciplinary groups
  • Keep current on trends, new products and technologies in the gene therapy and gene editing fields
  • Maintain laboratory equipment and facilities, as required
  • Report to one or more Research Scientist(s) – Gene Therapy

Poseida is a spinout of Transposagen Biopharmaceuticals, Inc., a leader in gene editing technologies. Poseida is currently developing CAR-T and gene therapy products for cancer and orphan liver diseases.  Poseida is also partnered with J&J’s Janssen to develop allogeneic CAR-T therapies against cancer.  Poseida has best-in-class genome engineering for stable transgene integration or targeted gene editing.  Proprietary platform technologies include piggyBac™ DNA Modification System (capable of delivering 300kb+ of cargo for stable integration and long-term expression), Footprint-Free™ Gene Editing System, NextGEN™ CRISPR, and XTN™ TALEN site-specific nucleases.  Poseida aims to advance the first CAR-T and gene therapy product candidates into Phase I clinical trials in early 2017.  Please visit www.poseida.com for more information.

Qualifications

Required Experience and Skills:

  • MS or equivalent in molecular biology, cell biology, hematology, virology or related field and, ideally, 2+ years of industry experience
  • Expertise with a range of molecular biology and cell biology techniques, such as PCR, qRT-PCR, mammalian cell culture and transfection, DNA/RNA and protein preparation, DNA sequencing, Western blotting, fluorescence imaging
  • Experience with flow cytometry and immune-staining (IHC/IFC)
  • Demonstrated expertise in gene delivery methods
  • Demonstrated ability to be independent, self-motivated, as well as work in a highly collaborative setting
  • Ability to work on multiple projects at once
  • Excellent oral and written communication skills
  • Attention to detail and excellent documentation skills
  • Excellent critical thinking and analytic skills and great trouble-shooting ability are required
  • Must be passionate about performing research that may lead to the treatment or cure of human disease